Wemos D1 mini Upload error

Hey There…
I’ve som Problems with uploading Firmware on Wemos D1.
Last week it works great, but now it dosent. I tryed new cable, New Wemos, re-install Atom and PlatformIO, VSCode and other PC’s.
Getting this from Terminal:

Executing task: C:\Users\Ruth.platformio\penv\Scripts\platformio.exe run --target upload <

[04/10/18 13:56:25] Processing nodemcuv2 (framework: arduino; platform: espressif; board: d1_mini)

Warning! Platform espressif is deprecated and will be removed in the next release! Please use espressif8266 instead.
Verbose mode can be enabled via -v, --verbose option
PLATFORM: Espressif 8266 > WeMos D1 R2 & mini
SYSTEM: ESP8266 160MHz 80KB RAM (4MB Flash)
Library Dependency Finder → Library Dependency Finder (LDF) — PlatformIO latest documentation
LDF MODES: FINDER(chain) COMPATIBILITY(light)
Collected 42 compatible libraries
Scanning dependencies…
Dependency Graph
|-- v1.0
|-- v1.1
| |-- v1.0
|-- v2.6
|-- v1.1.2
| |-- v1.2.3
| | |-- v1.0
| |-- v1.1.6
|-- v1.1.6
|-- v1.2.3
| |-- v1.0
|-- v1.0.2
|-- v0.12
| |-- v1.0
| |-- v1.0
| |-- v1.1.0
| | |-- v1.0
| |-- v1.0
| | |-- v1.0
|-- <thinger.io> v2.9.1
| |-- v1.0
| |-- v0.12
| | |-- v1.0
| | |-- v1.1.0
| | | |-- v1.0
| | |-- v1.0
| | | |-- v1.0
| |-- v1.1.0
| | |-- v1.0
| |-- v1.0
| | |-- v1.0
|-- v1.0.5
|-- v1.3.0
| |-- v1.0.2
|-- v5.13.1
|-- v0.5.2
| |-- v1.0
| |-- v1.5
|-- v1.1.3
| |-- v1.0
|-- v2.4.2
| |-- v1.0
| |-- v1.1.3
| | |-- v1.0
|-- v1.5
|--
| |-- v1.3.0
| | |-- v1.0.2
| |-- v1.0
| |-- v5.13.1
| |--
| | |-- v1.2.3
| | | |-- v1.0
| | |-- v1.1.6
| | |-- v1.1.2
| | | |-- v1.2.3
| | | | |-- v1.0
| | | |-- v1.1.6
| | |-- v1.0
| | | |-- v1.0
| | | |--
| | | | |-- v1.0
| | |-- v2.6
| | |--
| | | |-- v1.0
| | |-- v1.5
| | |-- v1.1
| | | |-- v1.0
| | | |-- v1.1
| | | | |-- v1.0
| | |-- v1.0
| | | |-- v1.0
| | | |-- v1.0
| | | | |-- v1.0
| | |-- v5.13.1
| | |-- v2.4.2
| | | |-- v1.0
| | | |-- v1.1.3
| | | | |-- v1.0
| | |-- v1.0
| | |-- v1.1
| | | |-- v1.0
| | |-- v1.0
| | | |-- v1.0
| | |-- v0.12
| | | |-- v1.0
| | | |-- v1.1.0
| | | | |-- v1.0
| | | |-- v1.0
| | | | |-- v1.0
| | |-- v0.5.2
| | | |-- v1.0
| | | |-- v1.5
| |-- v1.5
| |-- v1.0
| |-- v1.1
| | |-- v1.0
|--
| |-- v1.2.3
| | |-- v1.0
| |-- v1.1.6
| |-- v1.1.2
| | |-- v1.2.3
| | | |-- v1.0
| | |-- v1.1.6
| |-- v1.0
| | |-- v1.0
| | |--
| | | |-- v1.0
| |-- v2.6
| |--
| | |-- v1.0
| |-- v1.5
| |-- v1.1
| | |-- v1.0
| | |-- v1.1
| | | |-- v1.0
| |-- v1.0
| | |-- v1.0
|| | |-- v1.0
| | | |-- v1.0
| |-- v5.13.1
| |-- v2.4.2
| | |-- v1.0
| | |-- v1.1.3
| | | |-- v1.0
| |-- v1.0
| |-- v1.1
| | |-- v1.0
| |-- v1.0
| | |-- v1.0
| |-- v0.12
| | |-- v1.0
| | |-- v1.1.0
| | | |-- v1.0
| | |-- v1.0
| | | |-- v1.0
| |-- v0.5.2
| | |-- v1.0
| | |-- v1.5
Linking .pioenvs\nodemcuv2\firmware.elf
Checking program size
text data bss dec hex filename
500382 16516 32232 549130 8610a .pioenvs\nodemcuv2\firmware.elf
Building .pioenvs\nodemcuv2\firmware.bin
Configuring upload protocol…
Looking for upload port…
Auto-detected: COM10
Uploading .pioenvs\nodemcuv2\firmware.bin
error: Failed to open COM10
error: espcomm_open failed
error: espcomm_upload_mem failed
*** [upload] Error -1
=============================================================================================== [ERROR] Took 9.24 seconds ===============================================================================================
Der Terminalprozess wurde mit folgendem Exitcode beendet: 1

Das Terminal wird von Aufgaben wiederverwendet, drücken Sie zum Schließen eine beliebige Taste.

anyone an idea?

Greetz from Germany