Raspberry Pi Pico upload problem

Are you sure regular upload does not work if you copy the .uf2 file (pio\build\rpipico\firmware.uf2 ) once on the Pico’s boot drive?

Did you install libusb drivers via Zadig for the Boot interface? https://github.com/platformio/platform-raspberrypi/issues/2#issuecomment-828586398